Myeloid cells which secrete S100 proteins in juvenile dermatomyositis may contribute to disease activity
نویسندگان
چکیده
Background Juvenile dermatomyositis (JDM) is thought to involve an autoimmune myositis, yet the elements of the immune response which damage muscle tissue in JDM remain unclear. Muscle tissue from early JDM shows infiltration by predominantly macrophage/myeloid cells. Traditional histopathology would suggest that these cells have a scavenger or 'repair' function; our data suggest otherwise. We have analysed production of the highly proinflammatory S100 proteins MRP8/14 in JDM patients.
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عنوان ژورنال:
دوره 6 شماره
صفحات -
تاریخ انتشار 2008